Researchers detail in 'Rapid and recurrent neutrophil mobilization regulated by T134, a CXCR4 peptide antagonist,' new data in life sciences. "The CXCR4/stromal cell-derived factor-1 (SDF-1) axis plays important roles in development, leukocyte trafficking, HIV infection, and tumorigenesis. Its critical function in bone marrow stem cell and hematopoietic progenitor cell retention, homing and release has been well-characterized by genetic and pharmacological analyses," scientists writing in the journal Experimental Hematology report (see also Life Sciences).
"However, its role in neutrophil retention and release is still poorly understood. In this study, we demonstrated …
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